International Journal of Ayurveda Research International Journal of Ayurveda Research
  About IJAR | Editors | Search | Current Issue | Archives | Ahead Of Print | Instructions | Online submission | Advertise | Contact Us | Login 
Users Online: 61   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 1  |  Page : 18-24

Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats


1 Department of Bio-Medical Laboratory Science and Management, (U.G.C. Innovative Programme Funded Department), Vidyasagar University, Midnapore - 721 102; Ayurvedic Division, Southern Health Improvement Samity (SHIS), Bhangar, South 24 - Paraganas, West Bengal, India
2 Department of Bio-Medical Laboratory Science and Management, (U.G.C. Innovative Programme Funded Department), Vidyasagar University, Midnapore - 721 102, India

Correspondence Address:
Debidas Ghosh
Department of Bio-Medical Laboratory Science and Management, (U.G.C. Innovative Programme Funded Department), Vidyasagar University, Midnapore - 721 102, West Bengal
India
Login to access the Email id


DOI: 10.4103/0974-7788.59939

PMID: 20532093

Get Permissions

This study focuses on the effect of 'Diashis', a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with 'Diashis' in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by 'Diashis,' which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. 'Diashis' was not found to have any metabolic toxicity. The antidiabetic effects of 'Diashis' were compared with those of the antidiabetic drug, 'Glibenclamide'.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3121    
    Printed241    
    Emailed0    
    PDF Downloaded867    
    Comments [Add]    
    Cited by others 1    

Recommend this journal