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ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 205-207

Anti-inflammatory activity of Shirishavaleha: An ayurvedic compound formulation


1 Department of Rasashastra and Bhaishajya Kalpana Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar - 361 008, Gujarat, India
2 Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar - 361 008, Gujarat, India

Correspondence Address:
Galib
Department of Rasashastra and Bhaishajya Kalpana Including Drug Research,Institute for Post Graduate Teaching and Research in Ayurveda,Gujarat Ayurved University, Jamnagar - 361 008, Gujarat
India
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DOI: 10.4103/0974-7788.76781

PMID: 21455445

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The purpose of the present study was to evaluate the anti-inflammatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth.), viz. the bark (Twak) and the heartwood (Sara). The activity was screened in the carrageenan-induced rat paw edema model in albino rats. The raw materials were collected and authenticated in the university and the trial formulations were prepared by following standard classical guidelines. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 1.8 g/kg for 5 days. Phenylbutazone was used as the standard anti-inflammatory drug for comparison. Between the two different test samples studied, the formulation made from heartwood showed a weak anti-inflammatory activity in this model while that made from the bark produced a considerable suppression of edema after 6 h. It appears that the bark sample would be preferable for clinical use.


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