International Journal of Ayurveda Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 1  |  Issue : 1  |  Page : 18--24

Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats


Tushar K Bera1, Debasis De2, Kausik Chatterjee2, Kazi M Ali2, Debidas Ghosh2 
1 Department of Bio-Medical Laboratory Science and Management, (U.G.C. Innovative Programme Funded Department), Vidyasagar University, Midnapore - 721 102; Ayurvedic Division, Southern Health Improvement Samity (SHIS), Bhangar, South 24 - Paraganas, West Bengal, India
2 Department of Bio-Medical Laboratory Science and Management, (U.G.C. Innovative Programme Funded Department), Vidyasagar University, Midnapore - 721 102, India

Correspondence Address:
Debidas Ghosh
Department of Bio-Medical Laboratory Science and Management, (U.G.C. Innovative Programme Funded Department), Vidyasagar University, Midnapore - 721 102, West Bengal
India

This study focuses on the effect of «SQ»Diashis«SQ», a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with «SQ»Diashis«SQ» in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by «SQ»Diashis,«SQ» which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. «SQ»Diashis«SQ» was not found to have any metabolic toxicity. The antidiabetic effects of «SQ»Diashis«SQ» were compared with those of the antidiabetic drug, «SQ»Glibenclamide«SQ».


How to cite this article:
Bera TK, De D, Chatterjee K, Ali KM, Ghosh D. Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats.Int J Ayurveda Res 2010;1:18-24


How to cite this URL:
Bera TK, De D, Chatterjee K, Ali KM, Ghosh D. Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats. Int J Ayurveda Res [serial online] 2010 [cited 2014 Nov 28 ];1:18-24
Available from: http://www.ijaronline.com/article.asp?issn=0974-7788;year=2010;volume=1;issue=1;spage=18;epage=24;aulast=Bera;type=0