International Journal of Ayurveda Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 1  |  Issue : 3  |  Page : 159--162

Antioxidant and hypolipidemic activity of Kumbhajatu in hypercholesterolemic rats


Rumi Ghosh, Parag P Kadam, Vilasrao J Kadam 
 Department of Pharmacology, Bharati Vidyapeeth's College of Pharmacy, CBD, Belapur, Navi Mumbai, India

Correspondence Address:
Rumi Ghosh
Bharati Vidyapeeth«SQ»s College of Pharmacy, CBD, Belapur, Navi Mumbai
India

Objective: To study the efficacy of Kumbhajatu in reducing the cholesterol levels and as an antioxidant in hypercholesterolemic rats. Materials and Methods: Hypercholesterolemia was induced in normal rats by including 2% w/w cholesterol, 1% w/w sodium cholate and 2.5% w/w coconut oil in the normal diet. Powdered form of Kumbhajatu was administered as feed supplement at 250 and 500 mg/kg dose levels to the hypercholesterolemic rats. Plasma lipid profile, hepatic superoxide dismutase (SOD) activity, catalase activity, reduced glutathione and extent of lipid peroxidation in the form of malondialdehyde were estimated using standard methods. Results: Feed supplementation with 250 and 500 mg/kg of Kumbhajatu resulted in a significant decline in plasma lipid profiles. The feed supplementation increased the concentration of catalase, SOD, glutathione and HDL-c significantly in both the experimental groups (250 and 500 mg/kg). On the other hand, the concentration of malondialdehyde, cholesterol, triglycerides, LDL-c and VLDL in these groups (250 and 500 mg/kg) were decreased significantly. Conclusion: The present study demonstrates that addition of Kumbhajatu powder at 250 and 500 mg/kg level as a feed supplement reduces the plasma lipid levels and also decreases lipid peroxidation.


How to cite this article:
Ghosh R, Kadam PP, Kadam VJ. Antioxidant and hypolipidemic activity of Kumbhajatu in hypercholesterolemic rats.Int J Ayurveda Res 2010;1:159-162


How to cite this URL:
Ghosh R, Kadam PP, Kadam VJ. Antioxidant and hypolipidemic activity of Kumbhajatu in hypercholesterolemic rats. Int J Ayurveda Res [serial online] 2010 [cited 2014 Nov 1 ];1:159-162
Available from: http://www.ijaronline.com/article.asp?issn=0974-7788;year=2010;volume=1;issue=3;spage=159;epage=162;aulast=Ghosh;type=0