International Journal of Ayurveda Research

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 2  |  Issue : 1  |  Page : 14--22

Blood compatibility studies of Swarna bhasma (gold bhasma), an Ayurvedic drug


Willi Paul, Chandra Prakash Sharma 
 Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India

Correspondence Address:
Chandra Prakash Sharma
Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram - 695 012
India

Swarna bhasma (gold bhasma) preparations are widely utilized as therapeutic agents. However, in vitro biological evaluations of bhasma preparations are needed along with the physicochemical characterization for present day standardization of metallic bhasma preparations to meet the criteria that supports its use. Therefore, an attempt has been made to evaluate the protein adsorption, blood compatibility and complement activation potential of two batches of Swarna bhasma preparation, along with its physicochemical characterization. The particle size, morphology, elemental analysis, and in vitro cytotoxicity were evaluated initially. Red blood cell hemolysis, aggregation studies with blood cells, protein adsorption, complement C3 adsorption, platelet activation and tight junction permeability in Caco-2 cell line were investigated. The Swarna bhasma preparations with a crystallite size of 28-35 nm did not induce any blood cell aggregation or protein adsorption. Activation potential of these preparations towards complement system or platelets was negligible. These particles were also non-cytotoxic. Swarna bhasma particles opened the tight junctions in Caco-2 cell experiments. The results suggest the application of Swarna bhasma preparations as a therapeutic agent in clinical medicine from the biological safety point of view.


How to cite this article:
Paul W, Sharma CP. Blood compatibility studies of Swarna bhasma (gold bhasma), an Ayurvedic drug.Int J Ayurveda Res 2011;2:14-22


How to cite this URL:
Paul W, Sharma CP. Blood compatibility studies of Swarna bhasma (gold bhasma), an Ayurvedic drug. Int J Ayurveda Res [serial online] 2011 [cited 2014 Oct 21 ];2:14-22
Available from: http://www.ijaronline.com/article.asp?issn=0974-7788;year=2011;volume=2;issue=1;spage=14;epage=22;aulast=Paul;type=0